case report aspiration anesthesia semaglutide 2023 Semaglutide, delayed gastric emptying, and intraoperative pulmonary aspiration - Semaglutideand localanesthesia Regurgitation under anesthesia in a fasted patient prescribed semaglutide Unpacking the Risk: A Case Report on Semaglutide, Delayed Gastric Emptying, and Intraoperative Pulmonary Aspiration in 2023

Tirzepatideanesthesiaguidelines The landscape of medical treatments is constantly evolving, introducing new therapeutic agents with significant benefits and, sometimes, unexpected risks. In 2023, a growing body of evidence, particularly through case reports, has illuminated a potential concern surrounding the use of semaglutide, a popular glucagon-like peptide-1 (GLP-1) receptor agonist, and its association with delayed gastric emptying and an increased risk of pulmonary aspiration during anesthesiaGlucagon-Like Peptide 1 Receptor Agonists and Aspiration .... This article delves into these findings, synthesizing information from recent medical literature to provide a comprehensive understanding of the issue.

The Emergence of a Concern: Semaglutide and Gastric Motility

Semaglutide, widely prescribed for type 2 diabetes management and weight loss, exerts its effects by mimicking the action of GLP-12023年9月27日—Regurgitation underanesthesiain a fasted patient prescribedsemaglutidefor weight loss: acase report. Can J. Anaesth.2023Jun 6. doi .... One of its well-documented physiological effects is the deceleration of gastric emptying. While beneficial for glycemic control by promoting satiety and reducing postprandial glucose spikes, this effect can have significant implications in the perioperative setting. The delay in gastric emptying means that a patient may have more residual gastric contents even after the standard fasting period prior to surgery.

This phenomenon has been highlighted in numerous case reports published in 2023Pulmonary aspiration of gastric contents in two patients taking .... For instance, the Canadian Journal of Anesthesia featured several significant publications. One such case report by Klein et al. detailed a patient experiencing intraoperative pulmonary aspiration directly linked to their use of semaglutide for weight loss, which was associated with delayed gastric emptying. Similarly, another case report in the same journal discussed regurgitation under anesthesia in a fasted patient prescribed semaglutide, underscoring the potential for unexpected events.

Pulmonary Aspiration: A Serious Anesthesia Risk

Pulmonary aspiration occurs when foreign material, such as gastric contents, is inhaled into the lungs.作者：WB Beam·2023·被引用次数：37—Case reportsof retained solid gastric contents in patients undergoing anestheia. APSF Newsletter.2023;38:67,69–71. Are SeriousAnesthesiaRisks ofSemaglutide... This can lead to severe complications, including pneumonitis, pneumonia, and acute respiratory distress syndrome (ARDS)Risk of pulmonary aspiration during semaglutide use and .... The risk of pulmonary aspiration during semaglutide use and anesthesia in a fasting patient becomes a critical consideration for anesthesiologists. The presence of undigested food or liquids in the stomach, coupled with the physiological changes induced by anesthesia (such as relaxation of the lower esophageal sphincter and impaired protective airway reflexes), creates a precarious situation.Risk of pulmonary aspiration during semaglutide use and anesthesia in a fasting patient: a case report with tomographic evidence. November 2023; Einstein (Sà...

Several publications in 2023 have specifically addressed this emerging risk. The APSF Newsletter has reported on case reports of retained solid gastric contents in patients undergoing anesthesia who were on semaglutide.作者：WB Beam·2023·被引用次数：37—Case reportsof retained solid gastric contents in patients undergoing anestheia. APSF Newsletter.2023;38:67,69–71. Are SeriousAnesthesiaRisks ofSemaglutide... Furthermore, research exploring the relationship between perioperative semaglutide use and increased residual gastric content has provided quantitative data. Studies have indicated that a notable percentage of patients on semaglutide may have increased residual gastric content, even when adhering to fasting protocols, compared to those not using the medicationRisk of pulmonary aspiration during semaglutide use and .... For example, one study cited that 5.1% of patients not using semaglutide had increased residual gastric content, a figure that warrants comparison with those on the drug.

Case Report Evidence and Emerging Guidelines

The growing number of case reports regarding aspiration events associated with semaglutide has prompted a proactive approach from medical societies.作者：LL Fortis-Olmedo·2025·被引用次数：1—Semaglutide, delayed gastric emptying, and intraoperative pulmo- nary aspiration: a case report. Can J Anaesth. 2023;70(8):1394-6. https ... The American Society of Anesthesiologists (ASA) has been involved in discussions and the development of consensus-based recommendations.作者：LL Fortis-Olmedo·2025·被引用次数：1—The first case of bronchoaspiration was published in March 2023 in a 42-year-old patient on semaglutide for weight reduction. The patient was admitted to the ... While specific official semaglutide ASA guidelines might still be under development or evolving, the awareness within the anesthesia community is high. Publications like "Emerging Anesthesia Risks with Semaglutide" and "Implications of GLP-1 agonist use on airway management" reflect this heightened awareness and the ongoing scientific discourse.

The search intent behind queries like "Semaglutide, delayed gastric emptying, and intraoperative pulmonary aspiration" and "Risk of pulmonary aspiration during semaglutide use and anesthesia in a fasting patient" clearly indicates a desire for information on this specific complication and how to manage it.GLP-1 Agonists and the Risk of Pulmonary Aspiration ... Medical professionals are actively seeking to understand the nuances of anesthesia in patients taking these medicationsGlucagon-like peptide-1 receptor agonists before upper ....

Mitigation Strategies and Future Directions

Given the potential gravity of pulmonary aspiration, strategies to mitigate this risk are becoming increasingly important. These may include:

* Extended Fasting Periods: While standard fasting guidelines exist, physicians may consider extending fasting periods for patients on semaglutide, particularly those with a history of gastrointestinal issues or higher doses of the medication作者：W Alkabbani·2024·被引用次数：51—Regurgitation under anesthesia in a fasted patient prescribed semaglutidefor weight loss: a case report. Can J Anaesth 2023;70:1397-400..

* Preoperative Gastric Ultrasound: This non-invasive tool can help assess gastric content volume, providing valuable information to anesthesiologists about an individual patient's risk.

* Careful Airway Management: Employing vigilant airway management techniques during induction and emergence from anesthesia is paramount.

* Utilizing Alternative Agents or Protocols: In some high-risk scenarios, alternative anesthetic agents or protocols might be considered.Risk of pulmonary aspiration during semaglutide use and ...

The case report format has been instrumental in bringing this issue to the forefront作者：R Fezza·2023·被引用次数：14—Semaglutide, delayed gastric emptying, and intraoperative pulmonary aspiration: a case report. Can J Anaesth. 2023;70:1394–1396. Cited Here .... By documenting individual patient experiences, researchers and clinicians are building a robust picture of the potential adverse effects. As exemplified by the case reports appearing in journals like Einstein (São Paulo) and the Canadian Journal of Anesthesia, the consistent reporting of such events in 2023 and beyond signals a critical need for continued research and the establishment of clear perioperative guidelines. The search intent for "report" and "case" further emphasizes the importance of these documented instances in informing clinical practice.

In conclusion, the 2023 literature, particularly case reports, has brought to light a significant consideration for anesthesia providers: the potential for pulmonary aspiration in patients taking semaglutide due to delayed gastric emptying. While semaglutide offers considerable therapeutic advantages, awareness of this risk and the implementation of appropriate perioperative management strategies are crucial to ensure patient safety.Postoperative Aspiration Pneumonia Among Adults Using ... Continued research and the refinement of anesthesia protocols will be essential in navigating this evolving aspect of patient care.