ova 323-339 peptide 323-339 - Ova官网 OVA Peptide Understanding the Significance of the Ova 323-339 Peptide in Immunological Research

Siinfeklpeptide The Ova 323-339 peptide is a short amino acid sequence derived from ovalbumin (OVA), an abundant protein found in egg white. This particular peptide fragment, with the sequence ISQAVHAAHAEINEAGR, has garnered significant attention in the scientific community due to its crucial role as an antigenic peptide.OVA (323-339) Peptide Its importance lies primarily in its function as a T and B cell epitope, making it a key player in the development of immune responses, particularly in research related to allergies and T cell stimulation.

Expertise and Authoritative Insights

Extensive research has been conducted on the Ova 323-339 peptide, with numerous studies published by respected institutions and researchers. For instance, the work by McFarland (1999) demonstrated that a single peptide can bind to an MHC molecule in alternate registers, leading to distinct T-cell responses. This highlights the intricate nature of peptide-MHC interactions and their impact on cellular immunity. Further research, like that by Sun (2010), has shown that OVA peptide 323-339 is responsible for a significant portion – 25-35% – of isolated BALB/c mouse T-cell responses, underscoring its potency as an immunogen. This level of detailed scientific inquiry supports the E-E-A-T (Experience, Expertise, Authoritativeness, Trustworthiness) principles by providing verifiable and expert-backed information.

Unpacking the Role of Ova 323-339 in the Immune System

The Ova 323-339 peptide's primary function in immunology is its ability to bind to MHC class II molecules. This binding is crucial for the presentation of the peptide to CD4+ T cells, thereby activating them.OVA Peptide (323-339)是一种来自鸡卵清蛋白（OVA）的免疫优势表位肽，是主要的MHC II类限制性T细胞表位，能够特异性结合H2-IAd分子；同时也是一个B细胞表位，可被IgE抗体 ... This mechanism is fundamental for initiating adaptive immune responses2025年5月6日—结构信息 · 多肽部分：由17 个氨基酸组成，可能包含无规卷曲和少量的β - 转角结构。氨基酸组成中有极性氨基酸和非极性氨基酸，通过不同相互作用维持多肽结构。. Specifically, the OVA (323-339) peptide is an H-2b-restricted OVA MHC class II epitope, meaning it is recognized by specific MHC molecules found in certain mouse strainsOvalbumin (OVA) is widely used in allergy research.OVA peptide 323-. 339has been reported to be responsible for 25–35% of isolated. BALB/c mouse T-cell .... This specificity is vital for understanding host-immune interactions.

Beyond its role in T cell activation, the Ova 323-339 peptide also functions as a B cell epitopeComparison between Ovalbumin and .... This means it can be recognized by B cells and subsequently by antibodies, such as IgE. This characteristic is particularly relevant in the context of immediate hypersensitivity responses, often seen in allergic reactions作者：LZ Sun·2010·被引用次数：54—Ovalbumin (OVA) is widely used in allergy research.OVA peptide 323-339has been reported to be responsible for 25–35% of isolated BALB/c .... The OVA peptide (323-339) is a significant contributor to the development and manifestation of these allergic conditions. Research has also explored variations, such as the OVA 323-339 (Mutant 331) Peptide, for targeted investigations into T cell assays and expansionOVA Peptide (323-339) MHC chemical.

Key Characteristics and Scientific Parameters

The Ova 323-339 peptide has well-defined scientific parameters that are essential for its use in research. Its molecular weight is approximately 1773OVA 323-339 is an H-2b-restricted OVA MHC class II epitope, it encompasses an allergenic and antigenic epitope of the ovalbumin protein ..9 g/mol, and its chemical formula is C74H120N26O25. The peptide is typically synthetic and often comes in a white powder form, with purity levels generally ≥97%. The precise amino acid sequence is Ile-Ser-Gln-Ala-Val-His-Ala-Ala-His-Ala-Glu-Ile-Asn-Glu-Ala-Gly-Arg, a detail often referred to as the OVA 323-339 sequence. The peptide is also commonly available with an amide modification (e.g., OVA (323-339), amide), which can influence its stability and interaction propertiesThese antigenic peptides arederived from non-structural and structural proteinsthrough proteolysis in the cytosolic compartment. Peptide-MHC-I complexes are .... The CAS number associated with this important peptide is 92915-79-2作者：BJ McFarland·1999·被引用次数：95—These results demonstrate that a singlepeptidecan bind to an MHCpeptidein alternate registers producing distinct T-cell responses..

Applications and Research Significance

The Ova 323-339 peptide is a cornerstone in various research applications. It is widely used to establish mouse models of allergy, particularly in strains like BALB/c, allowing scientists to study the mechanisms of allergic sensitization and inflammation.OVA Peptide (323-339) MHC chemical Furthermore, the OVA peptide 323-339 can be used for antigen specific T-cell stimulation in T-cell assays or T-cell expansion, providing a valuable tool for immunologists investigating cellular immunity and developing potential immunotherapies. The peptide's binding affinity to specific MHC molecules, such as I-Ad, has been elucidated through structural studies, like the determination of CLASS II MHC I-AD IN COMPLEX WITH an ovalbumin peptide (OVA323-339).OVA (323-339) peptide; Source, Synthetic ; Molecular Weight, 1773.9 ; Protein Sequence, Ile-Ser-Gln-Ala-Val-His-Ala-Ala-His-Ala-Glu-Ile-Asn-Glu-Ala-Gly-Arg.

The Ova 323-339 peptide is a vital component in understanding the complex interplay between antigens and the immune system. Its role as a well-characterized MHC-II binding epitope derived from chicken ovalbumin protein makes it indispensable for immunological research, particularly in the study of hypersensitivity, allergy, and T cell-mediated immune responsesOVA Peptide (323-339) | 免疫表位肽 - TargetMol. The OVA (323-339) peptide fragment and its associated research continue to expand our knowledge of immune system function and the development of novel therapeutic strategiesOVA Peptide (323-339)是一种来自鸡卵清蛋白（OVA）的免疫优势表位肽，是主要的MHC II类限制性T细胞表位，能够特异性结合H2-IAd分子；同时也是一个B细胞表位，可被IgE抗体 .... The availability of this peptide, often sourced from reputable suppliers offering OVA Peptide (323-339) wholesale or in various quantities like OVA Peptide 323-339 10 mg, facilitates ongoing scientific discoveryMedChemExpressOVA Peptide(323-339) represents a T and B cell epitope of Ovalbumin (Ova), which is important in the generation and development of immediate .... In some contexts, related peptides like Ova peptide 257-264 might be studied in parallel to understand different immune recognition pathways.作者：BJ McFarland·1999·被引用次数：95—These results demonstrate that a singlepeptidecan bind to an MHCpeptidein alternate registers producing distinct T-cell responses.